Persistent Cardiac Dysfunction Following Treatment of Childhood Malignancy Is Related to Cumulative Anthracycline Dose
نویسندگان
چکیده
منابع مشابه
Mitral regurgitation after anthracycline treatment for childhood malignancy.
OBJECTIVE To investigate the new onset of mitral regurgitation in patients with otherwise normal echocardiograms after anthracycline treatment and to assess its relation to other selected indicators of myocardial damage. DESIGN Prospective echocardiographic and electrocardiographic study. SETTING Tertiary paediatric cardiac referral centre. PATIENTS 305 patients, aged 2-33 years (median 1...
متن کاملScreening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors.
PURPOSE To examine the utility and reliability of obtaining early echocardiographic measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac injury in asymptomatic childhood cancer survivors at risk for LV dysfunction and congestive heart failure due to past exposure to anthracycline chemotherapy. EXPERIMENTAL DESIGN Using a cross-sectional design, anthracycline...
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Mailing address: Odilson Marcos Silvestre • Rua Oscar Freire, 1.967, apto. 10B, Pinheiros. Postal Code 05409-011, São Paulo – SP – Brazil E-mail: [email protected], [email protected] Manuscript received April 16, 2013; manuscript revised April 16, 2013; accepted May 10, 2013.
متن کاملLeft ventricular diastolic function after anthracycline chemotherapy in childhood: relation with systolic function, symptoms, and pathophysiology.
OBJECTIVES To examine left ventricular (LV) diastolic function in patients previously treated with anthracycline drugs for childhood malignancy. To consider clinical relevance, relations with systolic dysfunction, and the pathophysiology of anthracycline cardiotoxicity. DESIGN Cross sectional echocardiographic study of LV function. SETTING Supraregional centre for paediatric cardiology, pri...
متن کاملMyocardial dysfunction late after low-dose anthracycline treatment in asymptomatic pediatric patients.
BACKGROUND The occurrence of chronic anthracycline cardiotoxicity leading to heart failure and even death is a major concern in the treatment of childhood malignancies. Currently, most treatment protocols use reduced anthracycline doses compared with historical exposure. The long-term effect of these reduced doses on myocardial function has not been well studied. METHODS We examined 56 asympt...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1999
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199904020-00181